I’m very excited to officially announce that I have a new book coming out next year!
“Introducing Epigenetics” is part of the Graphic Guides series by Icon Books. I’ve written the text, and artist Oliver Pugh is currently working on the illustrations. He’s done great work on earlier books in the series, and I can’t wait to see his artwork for Introducing Epigenetics!
The book covers all aspects of the exciting field of epigenetics, from the basics of gene regulation and embryonic development to the role of epigenetic modifications in diseases and their treatment, evolution, and the controversial field of epigenetic inheritance. I had a ton of fun writing it, even though it didn’t leave me with much time to do anything else last year!
The book will be available on February 2nd in the UK and March 14th in Canada, Australia, and the US. Other countries TBD.
More details, including links to online vendors, available here.
Dr A E A Porter
2017/08/20 at 11:11 am
Hi, I am in the process of reading your excellent little book “Epigenetics; A Graphic Guide” and I would like to draw to your attention an error on page 44 in your description of Frommer and Clark’s sodium bisulphite treatment of DNA which converts non methylated cytosine residues to Uracil residues and not as stated Thymine residues, leaving the methylated cytosine residues unchanged
2017/08/20 at 11:34 am
Hi, thanks for the comment. The section on BS sequencing was originally 2 pages long and included a more detailed explanation of the C->U conversion, and of how and why the sequencing chemistry and software read out uracil as thymine. The format of this series is very tight (100 words per page!), and we had to make a lot of cuts to get everything to fit. This meant we had to compact this section down into a single page, which meant there was no space for the uracil vs. thymine explanation. The reality is that when we look at the sequence reads in a BS library file we don’t see the Us at all, just Ts, so I thought it was OK.
I actually know Sue Clark a little bit and sent her the final version of the page for comment before printing; she never got back to me, but I’m going to get her to sign that page for me next time I see her (at a conference in October), so I’ll find out then what she thinks of it!
We had to cut the ChIP-Seq section down to a much simpler version too. The original version had an example of an actual track with peaks and troughs, but there just wasn’t space.
I hope you enjoy the rest of the book!